human IQSEC2 shRNA silencing AAV

Name
AAV-h-IQSEC2-shRNA

Cat No
shAAV-212383

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human IQSEC2.

shAAV-212383

AAV-h-IQSEC2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human IQSEC2 (IQ motif and Sec7 domain 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BRAG1; MRX1; MRX18; MRX78

Description (Vector)

IQSEC2 encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

23096

Gene Name (Vector)

IQ motif and Sec7 domain 2

Gene Symbol

IQSEC2

HGNC ID

HGNC:29059

ORF Size (aa)

2850

ORF Size (bp)

2850 bp

RefSeq ID

NM_015075

RefSeq Synonyms

NM_015075, NM_001243197, NM_001111125, BC156683,

Species

human

UniGene ID

Hs.496138

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.