human SEMA6D Adenovirus
This is an Adenovirus expressing Human SEMA6D.
ADV-222567
Ad-h-SEMA6D
Ready-to-use Adenovirus expressing Human SEMA6D (semaphorin 6D). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; semaphorin-6D
Description (eCommerce)
Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. Semaphorin-6D is a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing [taken from NCBI Entrez Gene (Gene ID: 80031)].
Description (Vector)
Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.
Gene ID
80031
Gene Name (eCommerce)
semaphorin 6D
Gene Name (Vector)
semaphorin 6D
Gene Symbol
SEMA6D
HGNC ID
HGNC:16770
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3036
ORF Size (bp)
3036 bp
Protein Name (eCommerce)
Semaphorin-6D
RefSeq ID
NM_020858
RefSeq Synonyms
NM_153619, NM_153618, NM_153617, NM_153616, NM_024966, NM_020858, NM_001198999, BC150253,
Research Areas
Axon Guidance,Golgi Apparatus,Neurobiology,Neurodevelopment,Neurogenesis,Signal Transduction,Translational Control
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. Semaphorin-6D is a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing [taken from NCBI Entrez Gene (Gene ID: 80031)].
UniGene ID
Hs.511265
UniProt ID (eCommerce)
Q8NFY4
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.