human ANGPTL4 Over-expression AAV

Name
AAV-h-ANGPTL4

Cat No
AAV-200919

Availability
4-5 weeks

This is an AAV expressing Human ANGPTL4.

AAV-200919

AAV-h-ANGPTL4

Ready-to-use AAV expressing Human ANGPTL4 (angiopoietin like 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158; TGQTL; UNQ171

Description (Vector)

ANGPTL4 is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. ANGPTL4 is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. ANGPTL4 was previously referred to as ANGPTL2 but has been renamed ANGPTL4.

Gene ID

51129

Gene Name (Vector)

angiopoietin like 4

Gene Symbol

ANGPTL4

HGNC ID

HGNC:16039

ORF Size (aa)

1221

ORF Size (bp)

1221 bp

RefSeq ID

NM_139314

RefSeq Synonyms

NM_139314, NM_001039667, BC023647,

Species

human

UniGene ID

Hs.9613

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.