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human PYHIN1 Adenovirus

Name 
Ad-h-PYHIN1
Cat No 
ADV-220458
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PYHIN1.

ADV-220458
Ad-h-PYHIN1

Ready-to-use Adenovirus expressing Human PYHIN1 (pyrin and HIN domain family member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
IFIX
Description (Vector)
PYHIN1 belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
149628
Gene Name (Vector)
pyrin and HIN domain family member 1
Gene Symbol
PYHIN1
HGNC ID
HGNC:28894
ORF Size (aa)
1452
ORF Size (bp)
1452 bp
RefSeq ID
NM_152501
RefSeq Synonyms
NM_198930, NM_198929, NM_198928, NM_152501, BC139741, BC090944, BC020822,
Species
human
UniGene ID
Hs.710248

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.