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human NUP210 shRNA silencing AAV

Name 
AAV-h-NUP210-shRNA
Cat No 
shAAV-217241
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NUP210.

shAAV-217241
AAV-h-NUP210-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NUP210 (nucleoporin 210). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GP210; nuclear envelope pore membrane protein POM 210; nuclear pore membrane glycoprotein 210; nuclear pore protein gp210; nucleoporin 210kDa; nucleoporin Nup210; POM210; pore membrane protein of 210 kDa
Description (eCommerce)
The nuclear pore complex (NPC) is a structure that spans the nuclear envelope and provides a conduit between the nucleus and cytoplasm for the nucleocytoplasmic transport of macromolecules. The main components of the NPC are nucleoporins. About 30 different human Nups have been identified and appear to serve non-redundant functions. Nup210 is a membrane-spanning glycoprotein and major component of the NPC. It is essential for nuclear envelope structure and cell viability. Autoantibodies to Nup210 have been observed in patients with primary biliary cirrhosis (PBC), an autoimmune liver disease.
Description (Vector)
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex.
Gene ID
23225
Gene Name (eCommerce)
nucleoporin 210
Gene Name (Vector)
nucleoporin 210
Gene Symbol
NUP210
HGNC ID
HGNC:30052
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2904
ORF Size (bp)
2904 bp
Protein Name (eCommerce)
Nuclear pore membrane glycoprotein 210
RefSeq ID
NM_024923
RefSeq Synonyms
NM_024923, BC067089,
Research Areas
Cell Cycle,Gene Expression,Host-Virus Interactions,Immunology,Metabolism/Metabolic Process,mRNA Processing,mRNA Transport,Ribonucleoprotein Transport,RNA Processing,RNA Transport,Signal Transduction,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,immunology,infectious_disease,metabolism,signal_transduction
Species
human
Target Sentence
The nuclear pore complex (NPC) is a structure that spans the nuclear envelope and provides a conduit between the nucleus and cytoplasm for the nucleocytoplasmic transport of macromolecules. The main components of the NPC are nucleoporins. About 30 different human Nups have been identified and appear to serve non-redundant functions. Nup210 is a membrane-spanning glycoprotein and major component of the NPC. It is essential for nuclear envelope structure and cell viability. Autoantibodies to Nup210 have been observed in patients with primary biliary cirrhosis (PBC), an autoimmune liver disease.
UniGene ID
Hs.475525
UniProt ID (eCommerce)
Q8TEM1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.