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human PVRL1 Adenovirus

Name 
Ad-h-PVRL1
Cat No 
ADV-220417
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PVRL1.

ADV-220417
Ad-h-PVRL1

Ready-to-use Adenovirus expressing Human NECTIN1 (nectin cell adhesion molecule 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD111;CD111;CLPED1;ectodermal dysplasia 4 (Margarita Island type);ED4;herpes simplex virus type 1 sensitivity;herpes virus entry mediator C;Herpesvirus entry mediator C;herpesvirus Ig-like receptor;HIgR;HV1S;HVEC;nectin 1;Nectin cell adhesion molecule 1;nectin-1;OFC7;poliovirus receptor-like 1;poliovirus receptor-related 1 (herpesvirus entry mediator C);poliovirus receptor-related protein 1;PRR;PRR1;PVRL1;PVRR;PVRR1;SK-12
Description (eCommerce)
PVRL1/NECTIN1 (aka CD111) is an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily. It acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2) and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells [taken from NCBI Entrez Gene (Gene ID: 5818)].
Description (Vector)
PVRL1 encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
Gene ID
5818
Gene Name (eCommerce)
nectin cell adhesion molecule 1
Gene Name (Vector)
nectin cell adhesion molecule 1
Gene Symbol
NECTIN1
HGNC ID
HGNC:9706
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1554
ORF Size (bp)
1554 bp
Protein Name (eCommerce)
Nectin-1
RefSeq ID
NM_002855
RefSeq Synonyms
NM_203286, NM_203285, NM_002855, BC113471, BC104948,
Research Areas
Axon Guidance,Cell Biology,Cytoskeleton,EGFR Signaling,Immunology,Neurobiology,Signal Transduction,Synapse,Translational Control,Transport
Research Areas (Faceted)
cell_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PVRL1/NECTIN1 (aka CD111) is an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily. It acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2) and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells [taken from NCBI Entrez Gene (Gene ID: 5818)].
UniGene ID
Hs.334846
UniProt ID (eCommerce)
Q15223

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.