human PRKAR2A Adenovirus

cAMP-dependent protein kinase regulatory subunit RII alpha; cAMP-dependent protein kinase type II-alpha regulatory subunit; PKR2; PRKAR2; protein kinase A, RII-alpha subunit; protein kinase, cAMP-dependent, regulatory subunit type II alpha

PRKAR2A/PKA-RIIalpha (cAMP-dependent protein kinase type II-alpha regulatory subunit) is one of 4 isoforms of regulatory subunits of the cAMP-dependent protein kinase (PKA). RI and RII are the two major classes of regulatory subunits. RI and RII each have an alpha and beta isoform. The regulatory subunits perform non-redundant functions as receptors for CAMP signals and for the differential regulation of PKA activity. The PRKAR2A/PKA-RIIalpha functions as an inhibitor of the PKA holoenzyme. PRKAR2A/PKA-RIIalpha subunits have been found to interact with A-kinase anchoring proteins (AKAPs), proteins that function to target the subcellular localization of PKA.

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).

5576

protein kinase cAMP-dependent type II regulatory subunit alpha

protein kinase cAMP-dependent type II regulatory subunit alpha

PRKAR2A

HGNC:9391

9606.0

1149

1149 bp

cAMP-dependent protein kinase type II-alpha regulatory subunit

NM_004157

NM_004157, NM_001321989, NM_001321983, NM_001321982, BC002763,

Apoptosis,Breast Cancer,Cancer,Cardiology,Cardiovascular,Cell Cycle,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,FGF Signaling,GPCR Signaling,Hedgehog Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Metabolism/Metabolic Process,Neurobiology,NGF Signaling,PDGF Signaling,Signal Transduction,TGF-beta Signaling,VEGF Signaling

cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,metabolism,neurobiology,signal_transduction

human

PRKAR2A/PKA-RIIalpha (cAMP-dependent protein kinase type II-alpha regulatory subunit) is one of 4 isoforms of regulatory subunits of the cAMP-dependent protein kinase (PKA). RI and RII are the two major classes of regulatory subunits. RI and RII each have an alpha and beta isoform. The regulatory subunits perform non-redundant functions as receptors for CAMP signals and for the differential regulation of PKA activity. The PRKAR2A/PKA-RIIalpha functions as an inhibitor of the PKA holoenzyme. PRKAR2A/PKA-RIIalpha subunits have been found to interact with A-kinase anchoring proteins (AKAPs), proteins that function to target the subcellular localization of PKA.

Hs.631923

P13861