human OPTN Adenovirus

Name 
Ad-h-OPTN
Cat No 
ADV-217450
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human OPTN.

ADV-217450
Ad-h-OPTN

Ready-to-use Adenovirus expressing Human OPTN (optineurin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ALS12; E3-14.7K-interacting protein; FIP2; FIP-2; GLC1E; HIP7; HIP-7; Huntingtin interacting protein L; huntingtin yeast partner L; huntingtin-interacting protein 7; huntingtin-interacting protein L; HYPL; nemo-related protein; NRP; optic neuropathy-inducing protein; optineurin; TFIIIA-INTP; transcription factor IIIA-interacting protein; transcrption factor IIIA-interacting protein; tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains
Description (eCommerce)
Defects in optineurin have been linked to glaucoma. In the cell, optineurin localizes to the Golgi and associates with markers of the endocytic pathway. A role in membrane trafficking and golgi function has been proposed due to its association with the actin-based motor protein myosin VI and its function as an effector protein of the small GTPase Rab8.
Description (Vector)
OPTN encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Gene ID
10133
Gene Name (eCommerce)
optineurin
Gene Name (Vector)
optineurin
Gene Symbol
OPTN
HGNC ID
HGNC:17142
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1716
ORF Size (bp)
1716 bp
Protein Name (eCommerce)
Optineurin
RefSeq ID
NM_021980
RefSeq Synonyms
NM_021980, NM_001008213, NM_001008212, NM_001008211, BC032762, BC013876,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Cell Cycle,Golgi Apparatus,Neurobiology,Neurodegeneration,Signal Transduction,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
Defects in optineurin have been linked to glaucoma. In the cell, optineurin localizes to the Golgi and associates with markers of the endocytic pathway. A role in membrane trafficking and golgi function has been proposed due to its association with the actin-based motor protein myosin VI and its function as an effector protein of the small GTPase Rab8.
UniGene ID
Hs.332706
UniProt ID (eCommerce)
Q96CV9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.