human NUP50 Adenovirus

Name 
Ad-h-NUP50
Cat No 
ADV-217248
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human NUP50.

ADV-217248
Ad-h-NUP50

Ready-to-use Adenovirus expressing Human NUP50 (nucleoporin 50). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
50 kDa nucleoporin; NPAP60; NPAP60L; nuclear pore complex protein Nup50; Nuclear pore-associated protein 60 kDa-like; nuclear pore-associated protein 60L; nucleoporin 50kD; nucleoporin 50kDa; nucleoporin Nup50
Description (eCommerce)
The nuclear pore complex (NPC) is a structure that spans the nuclear envelope and provides a conduit between the nucleus and cytoplasm for the nucleocytoplasmic transport of macromolecules. The main components of the NPC are nucleoporins. There are about 30 different human Nups that have been identified. Nup50 (also called Npap60) appears to not be a fixed structural component of the NPC. Nup50 has been shown to be a component of the importin complex, a protein carrier complex that imports cargo from the cytoplasm to the nucleus through the NPC. In this complex, Nup50 appears to have importance in the late stages of import and functions in complex disassembly and importin recycling.
Description (Vector)
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
10762
Gene Name (eCommerce)
nucleoporin 50
Gene Name (Vector)
nucleoporin 50
Gene Symbol
NUP50
HGNC ID
HGNC:8065
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1323
ORF Size (bp)
1323 bp
Protein Name (eCommerce)
Nuclear pore complex protein Nup50
RefSeq ID
NM_007172
RefSeq Synonyms
NM_153645, NM_007172, BC070133, BC028125, BC016055,
Research Areas
Cell Cycle,Gene Expression,Host-Virus Interactions,Immunology,Metabolism/Metabolic Process,mRNA Processing,mRNA Transport,Ribonucleoprotein Transport,RNA Processing,RNA Transport,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,immunology,infectious_disease,metabolism
Species
human
Target Sentence
The nuclear pore complex (NPC) is a structure that spans the nuclear envelope and provides a conduit between the nucleus and cytoplasm for the nucleocytoplasmic transport of macromolecules. The main components of the NPC are nucleoporins. There are about 30 different human Nups that have been identified. Nup50 (also called Npap60) appears to not be a fixed structural component of the NPC. Nup50 has been shown to be a component of the importin complex, a protein carrier complex that imports cargo from the cytoplasm to the nucleus through the NPC. In this complex, Nup50 appears to have importance in the late stages of import and functions in complex disassembly and importin recycling.
UniGene ID
Hs.715672
UniProt ID (eCommerce)
Q9UKX7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.