human MYH11 Adenovirus

Name 
Ad-h-MYH11
Cat No 
ADV-216159
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human MYH11.

ADV-216159
Ad-h-MYH11

Ready-to-use Adenovirus expressing Human MYH11 (myosin heavy chain 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AAT4; FAA4; SMHC; SMMHC
Description (Vector)
MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 (inv(16)(p13q22)) produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
4629
Gene Name (Vector)
myosin heavy chain 11
Gene Symbol
MYH11
HGNC ID
HGNC:7569
ORF Size (aa)
5838
ORF Size (bp)
5838 bp
RefSeq ID
NM_002474
RefSeq Synonyms
NM_022844, NM_002474, NM_001040114, NM_001040113, BC143364, BC104906, BC101677,
Species
human
UniGene ID
Hs.460109

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.