human MTPAP Adenovirus

Name 
Ad-h-MTPAP
Cat No 
ADV-216042
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human MTPAP.

ADV-216042
Ad-h-MTPAP

Ready-to-use Adenovirus expressing Human MTPAP (mitochondrial poly(A) polymerase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
mtPAP; PAP; PAP-associated domain-containing protein 1; PAPD1; poly(A) RNA polymerase, mitochondrial; polynucleotide adenylyltransferase; SPAX4; TENT6; terminal uridylyltransferase 1; TUTase 1
Description (eCommerce)
PAPD1 (mitochondrial poly(A) polymerase) is a polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. PAPD1 can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). It plays a role in replication-dependent histone mRNA degradation. It may be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated and might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA [taken from NCBI Entrez Gene (Gene ID: 55149)].
Description (Vector)
MTPAP is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.
Gene ID
55149
Gene Name (eCommerce)
mitochondrial poly(A) polymerase
Gene Name (Vector)
mitochondrial poly(A) polymerase
Gene Symbol
MTPAP
HGNC ID
HGNC:25532
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1749
ORF Size (bp)
1749 bp
Protein Name (eCommerce)
Poly(A) RNA polymerase, mitochondrial
RefSeq ID
NM_018109
RefSeq Synonyms
NM_018109, BC061703,
Research Areas
Apoptosis,Golgi Apparatus,Mitochondrion,mRNA Processing,Neurobiology,Neurodegeneration,RNA Binding,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,neurobiology,transcription_translation
Species
human
Target Sentence
PAPD1 (mitochondrial poly(A) polymerase) is a polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. PAPD1 can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). It plays a role in replication-dependent histone mRNA degradation. It may be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated and might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA [taken from NCBI Entrez Gene (Gene ID: 55149)].
UniGene ID
Hs.173946
UniProt ID (eCommerce)
Q9NVV4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.