human MRE11A Adenovirus
This is an Adenovirus expressing Human MRE11A.
ADV-215751
Ad-h-MRE11A
Ready-to-use Adenovirus expressing Human MRE11A (MRE11 homolog A, double strand break repair nuclease). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATLD; AT-like disease; DNA recombination and repair protein; double-strand break repair protein MRE11; double-strand break repair protein MRE11A; endo/exonuclease Mre11; HNGS1; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; MRE11 double strand break repair nuclease A; MRE11 homolog 1; MRE11 homolog A; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11-like protein A; MRE11A; MRE11B
Description (eCommerce)
Mre11 is a component of the MRN complex and plays a role in telomere maintenance and double-strand break (DSB) repair. Mre11 associates with rad50 in the MRN complex. Mre11 possesses 3’– 5’ exonuclease activity that is involved in creating DNA termini in DSB suitable for priming DNA synthesis and ligation.
Description (Vector)
MRE11A encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. MRE11A has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Gene ID
4361
Gene Name (eCommerce)
MRE11 homolog, double strand break repair nuclease
Gene Name (Vector)
MRE11 homolog A, double strand break repair nuclease
Gene Symbol
MRE11A
HGNC ID
HGNC:7230
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2127
ORF Size (bp)
2127 bp
Protein Name (eCommerce)
Double-strand break repair protein MRE11A
RefSeq ID
NM_005591
RefSeq Synonyms
NM_005591, NM_005590, NM_001330347, BC063458,
Research Areas
Cancer,Cardiology,Cell Biology,Cell Cycle,DNA Damage/Repair,Fanconi anemia,Helicase Activity,Homologous Recombination,Immunology,Innate Immunity,Meiosis,MicroRNAs in Cancer,Prostate Cancer,Signal Transduction,Telomeric Maintenance,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
Mre11 is a component of the MRN complex and plays a role in telomere maintenance and double-strand break (DSB) repair. Mre11 associates with rad50 in the MRN complex. Mre11 possesses 3’– 5’ exonuclease activity that is involved in creating DNA termini in DSB suitable for priming DNA synthesis and ligation.
UniGene ID
Hs.192649
UniProt ID (eCommerce)
P49959
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.