human MBD4 Adenovirus
This is an Adenovirus expressing Human MBD4.
ADV-215094
Ad-h-MBD4
Ready-to-use Adenovirus expressing Human MBD4 (methyl-CpG binding domain 4, DNA glycosylase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3,N(4)-ethenocytosine glycosylase; G/5-fluorouracil mismatch glycosylase with biphasic kinetics; G/T mismatch glycosylase; G/U mismatch glycosylase; MED1; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 4; methyl-CpG-binding endonuclease 1; methyl-CpG-binding protein MBD4; mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein
Description (eCommerce)
MBD4 (methyl-CpG-binding domain protein 4) is a member of the MBD family of proteins that mainly functions to bind methylated CpG sites and to repress gene transcription. Unlike its family members, MBD4 exhibits thymine glycosylase activity and has been shown to play an important role in DNA mismatch repair and apoptosis.
Description (Vector)
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.
Gene ID
8930
Gene Name (eCommerce)
methyl-CpG binding domain 4, DNA glycosylase
Gene Name (Vector)
methyl-CpG binding domain 4, DNA glycosylase
Gene Symbol
MBD4
HGNC ID
HGNC:6919
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1725
ORF Size (bp)
1725 bp
Protein Name (eCommerce)
Methyl-CpG-binding domain protein 4
RefSeq ID
NM_003925
RefSeq Synonyms
NM_003925, NM_001276273, NM_001276272, NM_001276271, NM_001276270, BC011752,
Research Areas
Apoptosis,DNA Damage/Repair
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
MBD4 (methyl-CpG-binding domain protein 4) is a member of the MBD family of proteins that mainly functions to bind methylated CpG sites and to repress gene transcription. Unlike its family members, MBD4 exhibits thymine glycosylase activity and has been shown to play an important role in DNA mismatch repair and apoptosis.
UniGene ID
Hs.35947
UniProt ID (eCommerce)
O95243
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.