human MAPK8IP1 Adenovirus
This is an Adenovirus expressing Human MAPK8IP1.
ADV-214987
Ad-h-MAPK8IP1
Ready-to-use Adenovirus expressing Human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IB1; JIP-1; JIP1; PRKM8IP
Description (Vector)
MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. MAPK8IP1 is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Gene ID
9479
Gene Name (Vector)
mitogen-activated protein kinase 8 interacting protein 1
Gene Symbol
MAPK8IP1
HGNC ID
HGNC:6882
ORF Size (aa)
2136
ORF Size (bp)
2136 bp
RefSeq ID
NM_005456
RefSeq Synonyms
NM_005456, BC068470,
Species
human
UniGene ID
Hs.234249
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.