human MAP2K4 Adenovirus

Name
Ad-h-MAP2K4

Cat No
ADV-214918

Availability
4-5 weeks

This is an Adenovirus expressing Human MAP2K4.

ADV-214918

Ad-h-MAP2K4

Ready-to-use Adenovirus expressing Human MAP2K4 (mitogen-activated protein kinase kinase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

c-Jun N-terminal kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 4; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; JNKK1; MAP kinase kinase 4; MAPK/ERK kinase 4; MAPKK 4; MAPKK4; MEK 4; MEK4; MKK4; PRKMK4; SAPK kinase 1; SAPK/ERK kinase 1; SAPKK1; SAPKK-1; SEK1; SERK1; SKK1; stress-activated protein kinase kinase 1

Description (eCommerce)

MAPKK4 (mitogen-activated protein kinase kinase 4) is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. MAPKK4 is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. Studies in knockout mice suggest that MAPKK4 mediates survival signals in T cell development. It may also be important to liver organogenesis.[taken from NCBI Entrez Gene (GeneID: 6416)].

Description (Vector)

MAP2K4 encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.

Gene ID

6416

Gene Name (eCommerce)

mitogen-activated protein kinase kinase 4

Gene Name (Vector)

mitogen-activated protein kinase kinase 4

Gene Symbol

MAP2K4

HGNC ID

HGNC:6844

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1200

ORF Size (bp)

1200 bp

Protein Name (eCommerce)

Dual specificity mitogen-activated protein kinase kinase 4

RefSeq ID

NM_003010

RefSeq Synonyms

NM_003010, NM_001281435, BC060764, BC036032,

Research Areas

Angiogenesis,Apoptosis,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD40 Signaling,CD95/FAS Signaling,Cytokine Signaling,EPO Signaling,Fc Receptor Signaling,Glioma,GnRH Signaling,HGF Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,MAPK Signaling,Neurobiology,PDGF Signaling,RAC1 Signaling,Rho Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,TRAIL Signaling,VEGF Signaling,Wnt Signaling

Research Areas (Faceted)

cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction

Species

human

Target Sentence

UniGene ID

Hs.514681

UniProt ID (eCommerce)

P45985

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.