human MADD Adenovirus

Name 
Ad-h-MADD
Cat No 
ADV-214785
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human EIF3CL.

ADV-214785
Ad-h-MADD

Ready-to-use Adenovirus expressing Human MADD (MAP kinase activating death domain). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DENN; differentially expressed in normal and neoplastic cells; IG20; insulinoma glucagonoma clone 20; MAP kinase-activating death domain protein; Rab3 GDP/GTP exchange factor; RAB3GEP
Description (eCommerce)
MAP kinase-activating death domain protein (MADD) is a death domain containing protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activate protein kinase (MAPK) and transduce apoptotic signals. MADD is a multi-pass membrane protein that exists as multiple alternatively spliced forms.
Description (Vector)
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.
Gene ID
8567
Gene Name (eCommerce)
MAP kinase activating death domain
Gene Name (Vector)
MAP kinase activating death domain
Gene Symbol
MADD
HGNC ID
HGNC:6766
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4635
ORF Size (bp)
4635 bp
Protein Name (eCommerce)
MAP kinase-activating death domain protein
RefSeq ID
NM_003682
RefSeq Synonyms
NM_130476, NM_130475, NM_130474, NM_130473, NM_130472, NM_130471, NM_130470, NM_003682, NM_001135944, NM_001135943, BC040484,
Research Areas
Apoptosis,Bladder Cancer,Cancer,Cell Cycle,Signal Transduction,TNF Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
MAP kinase-activating death domain protein (MADD) is a death domain containing protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activate protein kinase (MAPK) and transduce apoptotic signals. MADD is a multi-pass membrane protein that exists as multiple alternatively spliced forms.
UniGene ID
Hs.82548
UniProt ID (eCommerce)
Q8WXG6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.