human ITGAE Adenovirus

Name 
Ad-h-ITGAE
Cat No 
ADV-212489
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ITGAE.

ADV-212489
Ad-h-ITGAE

Ready-to-use Adenovirus expressing Human ITGAE (integrin subunit alpha E). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
alpha polypeptide; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; CD antigen CD103; CD103; HML-1 antigen; human mucosal lymphocyte antigen 1, alpha polypeptide; HUMINAE; integrin alpha-E; integrin alpha-IEL; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1); mucosal lymphocyte 1 antigen
Description (eCommerce)
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD103/ITGAE is an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, CD103/ITGAE forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen, and is preferentially expressed in human intestinal intraepithelial T-lymphocytes (IEL). In addition to a role in adhesion, CD103/ITGAE may serve as an accessory molecule for IEL activation. [taken from NCBI Entrez Gene (Gene ID: 3682)].
Description (Vector)
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.
Gene ID
3682
Gene Name (eCommerce)
integrin subunit alpha E
Gene Name (Vector)
integrin subunit alpha E
Gene Symbol
ITGAE
HGNC ID
HGNC:6147
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3540
ORF Size (bp)
3540 bp
Protein Name (eCommerce)
Integrin alpha-E
RefSeq ID
NM_002208
RefSeq Synonyms
NM_002208, BC117207, BC113436,
Research Areas
Cytoskeleton,Signal Transduction
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD103/ITGAE is an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, CD103/ITGAE forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen, and is preferentially expressed in human intestinal intraepithelial T-lymphocytes (IEL). In addition to a role in adhesion, CD103/ITGAE may serve as an accessory molecule for IEL activation. [taken from NCBI Entrez Gene (Gene ID: 3682)].
UniGene ID
Hs.513867
UniProt ID (eCommerce)
P38570

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.