human HMGN3 Adenovirus

Name 
Ad-h-HMGN3
Cat No 
ADV-211305
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human CREM.

ADV-211305
Ad-h-HMGN3

Ready-to-use Adenovirus expressing Human HMGN3 (high mobility group nucleosomal binding domain 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
high mobility group nucleosome-binding domain-containing protein 3; PNAS-24; PNAS-25; thyroid hormone receptor interacting protein 7; Thyroid receptor-interacting protein 7; TR-interacting protein 7; TRIP7; TRIP-7
Description (eCommerce)
HMGN3 was originally identified in a screen for interaction partners of the thyroid hormone receptor. HMGN3 belongs to the HMGN family of small basic proteins that interacts specifically with nucleosomes and functions to facilitate chromatin unfolding to allow access of transcription factors to DNA targets. HMGN has been found to be a regulator of the glycine transporter 1 (GLYT1) gene.
Description (Vector)
Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
9324
Gene Name (eCommerce)
high mobility group nucleosomal binding domain 3
Gene Name (Vector)
high mobility group nucleosomal binding domain 3
Gene Symbol
HMGN3
HGNC ID
HGNC:12312
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
234
Protein Name (eCommerce)
High mobility group nucleosome-binding domain-containing protein 3
RefSeq ID
NM_004242
RefSeq Synonyms
NM_138730, NM_004242, NM_001318888, NM_001318887, NM_001318886, NM_001318885, NM_001318884, NM_001201363, NM_001201362, BC009529,
Research Areas
Chromatin Remodeling
Research Areas (Faceted)
cell_biology,genetics
Species
human
Target Sentence
HMGN3 was originally identified in a screen for interaction partners of the thyroid hormone receptor. HMGN3 belongs to the HMGN family of small basic proteins that interacts specifically with nucleosomes and functions to facilitate chromatin unfolding to allow access of transcription factors to DNA targets. HMGN has been found to be a regulator of the glycine transporter 1 (GLYT1) gene.
UniGene ID
Hs.77558
UniProt ID (eCommerce)
Q15651

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.