mouse MET shRNA Adenovirus
This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown mouse MET gene. The shRNA expression is driven by an U6 promoter.
The knockdown of this mouse gene was validated by qPCR in MLP29 cells.
1849
Ad-m-MET-shRNA
Ready-to-use mouse MET shRNA Adenovirus. mouse MET shRNA adenovirus gene knockdown1849
Gene Reference Data
Alternate Names
AI838057; c-Met; HGF; HGFR; Par4
Description (Vector)
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells|Function: Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
Gene ID
17295
Gene Name (Vector)
met proto-oncogene
Gene Symbol
Met
ORF Size (aa)
4137
ORF Size (bp)
4137 bp
RefSeq ID
NM_008591
RefSeq Synonyms
NM_008591, BC156287,
Species
mouse
UniGene ID
Mm.86844
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.