human GBF1 Adenovirus
This is an Adenovirus expressing Human GBF1.
ADV-209708
Ad-h-GBF1
Ready-to-use Adenovirus expressing Human GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ARF1GEF; BFA-resistant GEF 1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Description (eCommerce)
GBF1 is a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP for GTP on ADP ribosylation factor 5(ARF5). GBF1 activity is inhibited by brefeldin, an antibiotic that interferes with protein transport. It has been show to be important to golgi assembly and the coordination of bidirectional transport. Due to these characteristics, GBF1 is also called Golgi-specific brefeldin A-resistance GEF 1.
Description (Vector)
GBF1 encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene.
Gene ID
8729
Gene Name (eCommerce)
golgi brefeldin A resistant guanine nucleotide exchange factor 1
Gene Name (Vector)
golgi brefeldin A resistant guanine nucleotide exchange factor 1
Gene Symbol
GBF1
HGNC ID
HGNC:4181
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5568
ORF Size (bp)
5568 bp
Protein Name (eCommerce)
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
RefSeq ID
NM_004193
RefSeq Synonyms
NM_004193, NM_001199379, NM_001199378, BC117682, BC117681,
Research Areas
Golgi Apparatus,Host-Virus Interactions,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,infectious_disease
Species
human
Target Sentence
GBF1 is a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP for GTP on ADP ribosylation factor 5(ARF5). GBF1 activity is inhibited by brefeldin, an antibiotic that interferes with protein transport. It has been show to be important to golgi assembly and the coordination of bidirectional transport. Due to these characteristics, GBF1 is also called Golgi-specific brefeldin A-resistance GEF 1.
UniGene ID
Hs.290243
UniProt ID (eCommerce)
Q92538
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.