human GCG shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GCG.
shAAV-209735
AAV-h-GCG-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GCG (glucagon). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GLP1; GLP2; GRPP
Description (Vector)
GCG is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
Gene ID
2641
Gene Name (Vector)
glucagon
Gene Symbol
GCG
HGNC ID
HGNC:4191
ORF Size (aa)
543
RefSeq ID
NM_002054
RefSeq Synonyms
NM_002054, BC005278,
Species
human
UniGene ID
Hs.516494
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.