Signal transducer and activator of transcription 2 Adenovirus

Name 
Ad-STAT2
Cat No 
1614
Availability
Immediate
Categories
Adenovirus, Over-Expression

Stats (signal transducers and activators of transcription) are tyrosine phosphorylated transcription factors activated by JAK family kinases. Various ligands, including interferons and growth factors, induce activation of the JAK kinases, which induce Stat activation. Stat1 and Stat2 are induced by IFN-α and form a heterodimer that is part of the ISGF-3 transcription factor complex. Stat3β is activated by EGF and IL-6. Stat3α is activated by EGF. Highest expression of Stat4 is observed in the testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 can be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways. Stat-1 and Stat-3 bind the serum-inducible element (SIE) and GAS/ISRE elements are also known to be STAT-binding sites.

1614
Ad-STAT2

Ready-to-use Signal transducer and activator of transcription 2 Adenovirus. Ad-STAT2, Signal transducer and activator of transcription 2, P113, STAT2, ISGF-3, STAT113, STAT-2 adenovirus 1614

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
IMD44; interferon alpha induced transcriptional activator; ISGF-3; P113; signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT113
Description (eCommerce)
Signal transducer and activator of transcription 2 (STAT2) is a signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P52630].
Description (Vector)
STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
6773
Gene Name (eCommerce)
signal transducer and activator of transcription 2
Gene Name (Vector)
signal transducer and activator of transcription 2
Gene Symbol
STAT2
HGNC ID
HGNC:11363
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2556
ORF Size (bp)
2556 bp
Protein Name (eCommerce)
Signal transducer and activator of transcription 2
RefSeq ID
NM_005419
RefSeq Synonyms
NM_198332, NM_005419, BC051284,
Research Areas
Cancer,Cytokine Signaling,EGFR Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Interleukin Signaling,JAK-STAT Signaling,Response to Virus,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
Signal transducer and activator of transcription 2 (STAT2) is a signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P52630].
UniGene ID
Hs.530595
UniProt ID (eCommerce)
P52630

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.