human FLJ45422 Adenovirus

Name
Ad-h-FLJ45422

Cat No
ADV-209149

Availability
4-5 weeks

This is an Adenovirus expressing Human FLJ45422.

ADV-209149

Ad-h-FLJ45422

Ready-to-use Adenovirus expressing Human HLA-C (major histocompatibility complex, class I, C). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

D6S204; HLA-JY3; HLAC; HLC-C; MHC; PSORS1

Description (Vector)

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described

Gene ID

3107

Gene Name (Vector)

major histocompatibility complex, class I, C

Gene Symbol

HLA-C

HGNC ID

HGNC:4933

ORF Size (aa)

1101

ORF Size (bp)

1101 bp

RefSeq ID

NM_002117

RefSeq Synonyms

NM_002117, NM_001243042, BC033293, BC008457, BC002463,

Species

human

UniGene ID

Hs.656020

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.