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human FLJ45422 Over-expression AAV

Name 
AAV-h-FLJ45422
Cat No 
AAV-209148
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HLA-C.

AAV-209148
AAV-h-FLJ45422

Ready-to-use AAV expressing Human HLA-C (major histocompatibility complex, class I, C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
D6S204; HLA-JY3; HLAC; HLC-C; MHC; PSORS1
Description (Vector)
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
Gene ID
3107
Gene Name (Vector)
major histocompatibility complex, class I, C
Gene Symbol
HLA-C
HGNC ID
HGNC:4933
ORF Size (aa)
1101
ORF Size (bp)
1101 bp
RefSeq ID
NM_002117
RefSeq Synonyms
NM_002117, NM_001243042, BC033293, BC008457, BC002463,
Species
human
UniGene ID
Hs.656020

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.