Cyclin-dependent kinase 7 Adenovirus
Cyclin dependent kinases (Cdks) are critical regulators of cell cycle progression that are constitutively expressed throughout the cell cycle. Family members include Cdc2 p34, Cdk2-9, PITSLRE, PCTAIRE-1-3, KKIAMRE, KKIALRE and NKIAMRE. Prototype members of this family include Cdc2 p34 and Cdk2, which function late in the cell cycle, whereas other members, Cdk4, Cdk6 and a related protein Cdc7, are critically involved in the G1 and S phase transitions. Cdks comprise the catalytic subunit of the cell cycle kinases and they associate with specific regulatory subunits to form an active complex. Cyclin H is one such regulatory subunit that preferentially binds to Cdk7 and forms the cyclin H/Cdk7 complex, which then phosphorylates Cdc2, Cdk2 and Cdk4 to regulate cell cycle progression.
1568
Ad-CDK7
Ready-to-use Cyclin-dependent kinase 7 Adenovirus. Ad-CDK7, Cyclin-dependent kinase 7, CAK1, CDK7, STK1, CDKN7, P39MO15 adenovirus 1568
Gene Reference Data
Alternate Names
39 KDa protein kinase; CAK; CAK1; CDK-activating kinase 1; CDKN7; cell division protein kinase 7; cyclin-dependent kinase 7; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); HCAK; homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; MO15; p39 Mo15; p39MO15; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; Serine/threonine-protein kinase 1; STK1; TFIIH basal transcription factor complex kinase subunit
Description (eCommerce)
Cyclin-dependent kinase 7 (CDK7) is a member of the CDK family of protein kinases that regulate cell cycle progression. CDK7 is the catalytic subunit in a trimeric complex with cyclin H and MAT1 that functions as a Cdk-activating kinase (CAK). CDK7 activates the kinase activities of CDK1, CDK2, CDK4, and CDK6 by threonine phosphorylation. In addition to its cell cycle function CDK7 has also been found to be an essential component of the transcription factor TFIIH. Several substrates of CDK7 are involved in transcription, further indicating a role in transcription.
Description (Vector)
CDK7 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
Gene ID
1022
Gene Name (eCommerce)
cyclin dependent kinase 7
Gene Name (Vector)
cyclin dependent kinase 7
Gene Symbol
CDK7
HGNC ID
HGNC:1778
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1041
ORF Size (bp)
1041 bp
Protein Name (eCommerce)
Cyclin-dependent kinase 7
RefSeq ID
NM_001799
RefSeq Synonyms
NM_001799, NM_001324078, NM_001324077, NM_001324075, NM_001324074, NM_001324072, NM_001324071, NM_001324070, NM_001324069, BC005298, BC000834,
Research Areas
B-cell Receptor Signaling,Breast Cancer,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Cell Division,Cytoskeleton,DNA Damage/Repair,Epigenetic Regulation of Gene Expression,EPO Signaling,Gene Expression,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Mitochondrion,mRNA Processing,Nuclear Receptor Coactivators,RNA Processing,Signal Transduction,Transcription Factor/Regulator,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
Cyclin-dependent kinase 7 (CDK7) is a member of the CDK family of protein kinases that regulate cell cycle progression. CDK7 is the catalytic subunit in a trimeric complex with cyclin H and MAT1 that functions as a Cdk-activating kinase (CAK). CDK7 activates the kinase activities of CDK1, CDK2, CDK4, and CDK6 by threonine phosphorylation. In addition to its cell cycle function CDK7 has also been found to be an essential component of the transcription factor TFIIH. Several substrates of CDK7 are involved in transcription, further indicating a role in transcription.
UniGene ID
Hs.184298
UniProt ID (eCommerce)
P50613
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.