v-myb myeloblastosis viral oncogene homolog (avian)-like 2 Adenovirus

Name 
Ad-b-Myb
Cat No 
1562
Availability
Immediate
Categories
Adenovirus, Over-Expression

The Myb family of transcription factors regulate differentiation and cellular growth through binding to promoters with the consensus sequence 5′-AAC(G/T)G-3′ and transactivating gene expression. The proto-oncogene c-Myb is the cellular homolog of the leukemogenic avian retroviral protein v-Myc, and c-Myc is expressed predominantly in immature and rapidly dividing hematopoietic cells. Additional members of the family include B-Myb, a 110 kDa protein that is expressed in a wide variety of proliferating cells at the G1 to S phase transition, and A-Myb, which is expressed in reproductive tissues, some neural cells and a subset of normal and neoplastic B lymphocytes. Transactivation properties of B-Myb are apparently dependent upon the protein’s hyperphosphorylation at several C-terminal residues, including Thr 447, Thr 490, Thr 497 and Ser 581. Dmp1 is related to the Myb family and also functions as a transcriptional activator. Dmp1 contains three tandem Myb repeats and is a putative substrate for cyclin D-dependent kinase.

1562
Ad-b-Myb

Ready-to-use v-myb myeloblastosis viral oncogene homolog (avian)-like 2 Adenovirus. Ad-b-Myb, v-myb myeloblastosis viral oncogene homolog (avian)-like 2, BMYB, MYBL2 adenovirus 1562

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
BMYB; B-MYB; myb-like protein 2; myb-related protein B; v-myb avian myeloblastosis viral oncogene homolog-like 2; v-myb myeloblastosis viral oncogene homolog-like 2
Description (eCommerce)
B-myb is transcription factor involved in multiple cellular processes such as cell survival, proliferation, and differentiation. B-myb was identified in a low-stringency screen of a T-cell cDNA library probed with a C-myb probe. C-myb is a cellular proto-oncogene highly conserved in vertebrates and invertebrates. The chicken c-myb proto-oncogene was the first ortholog discovered. Investigation of the origins of the avian myeloblastosis virus (AMV) led to the discovery that the AMV genome contained transduced sequences from normal chicken cellular DNA that resulted in a viral oncogenic version (v-myb) of the c-myb gene. B-myb is cell cycle regulated and expressed in all proliferating cells. Recent studies show that it is the only myb family member detected in embryonic stem cells and is essential to cell cycle progression and genomic stability.
Description (Vector)
MYBL2, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.
Gene ID
4605
Gene Name (eCommerce)
MYB proto-oncogene like 2
Gene Name (Vector)
MYB proto-oncogene like 2
Gene Symbol
MYBL2
HGNC ID
HGNC:7548
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2103
ORF Size (bp)
2103 bp
Protein Name (eCommerce)
Myb-related protein B
RefSeq ID
NM_002466
RefSeq Synonyms
NM_002466, NM_001278610, BC053555, BC007585,
Research Areas
Cancer,Cell Cycle,EGFR Signaling,Host-Virus Interactions,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,infectious_disease,genetics,transcription_translation
Species
human
Target Sentence
B-myb is transcription factor involved in multiple cellular processes such as cell survival, proliferation, and differentiation. B-myb was identified in a low-stringency screen of a T-cell cDNA library probed with a C-myb probe. C-myb is a cellular proto-oncogene highly conserved in vertebrates and invertebrates. The chicken c-myb proto-oncogene was the first ortholog discovered. Investigation of the origins of the avian myeloblastosis virus (AMV) led to the discovery that the AMV genome contained transduced sequences from normal chicken cellular DNA that resulted in a viral oncogenic version (v-myb) of the c-myb gene. B-myb is cell cycle regulated and expressed in all proliferating cells. Recent studies show that it is the only myb family member detected in embryonic stem cells and is essential to cell cycle progression and genomic stability.
UniGene ID
Hs.179718
UniProt ID (eCommerce)
P10244

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.