Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) Adenovirus
The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. The human sirtuins, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT1 is widely expressed and regulates p53 function through its deacetylation at lysine 382.
1556
Ad-SIRT6
Ready-to-use Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) Adenovirus. Ad-SIRT6, Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae), SIRT6, SIR2L6 adenovirus 1556
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Gene Reference Data
Alternate Names
NAD-dependent protein deacetylase sirtuin-6; regulatory protein SIR2 homolog 6; SIR2L6; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6
Description (eCommerce)
Sirtuin 6 (Sirt6) is a NAD-dependent protein deacetylase. Sirt6 displays deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Sirt6 also deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Sirt6 is important for the modulation of cellular senescence and apoptosis and the maintenance of telomeres and genomic stability [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8N6T7].
Description (Vector)
SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
Gene ID
51548
Gene Name (eCommerce)
sirtuin 6
Gene Name (Vector)
sirtuin 6
Gene Symbol
SIRT6
HGNC ID
HGNC:14934
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
987
Protein Name (eCommerce)
NAD-dependent protein deacetylase sirtuin-6
RefSeq ID
NM_016539
RefSeq Synonyms
NM_016539, NM_001321064, NM_001321063, NM_001321062, NM_001321061, NM_001321060, NM_001321059, NM_001321058, NM_001193285, BC028220, BC005026, BC004218,
Research Areas
Aging,Chromatin Remodeling,DNA Damage/Repair,Histone Modification,Telomeric Maintenance
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Sirtuin 6 (Sirt6) is a NAD-dependent protein deacetylase. Sirt6 displays deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Sirt6 also deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Sirt6 is important for the modulation of cellular senescence and apoptosis and the maintenance of telomeres and genomic stability [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8N6T7].
UniGene ID
Hs.423756
UniProt ID (eCommerce)
Q8N6T7
Related Citations
- The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other’s activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy. A Kanwal,etc, (2019), The FASEB Journal
- Oxidative Stress Induces Endothelial Cell Senescence via Downregulation of Sirt6. Rong Liu, etc, (2014), Hindawi
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.