Phospholipase C, delta 4 Adenovirus

Name 
Ad-PLC(delta 4)
Cat No 
1552
Availability
Immediate
Categories
Adenovirus, Over-Expression

Phospholipase C gamma1 (PLC gamma1), a phosphatidylinositol-4,5-bisphosphate (PI-4,5-P2)-specific phosphodiesterase plays a critical role in the initiation of receptor-mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol, from phosphatidylinositol-4,5-bisphosphate. A total of nine mammalian PLC isozymes have been described (PLC beta1, PLC beta2, PLC beta3, PLC beta4, PLC gamma1, PLC gamma2, PLC zeta1, PLC delta2 and PLC epsilon) with molecular weights ranging from 85 to 255 kDa. The gamma-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two gamma-type enzymes, but not the beta and zeta isozymes, are subject to activation by a number of protein tyrosine kinases, which associate with SH2 domains and induce their activation by phosphorylation. In contrast, activation of PLC beta1, PLC beta2 and PLC beta3 is mediated by the alpha subunits of the Gq class of heterotrimeric G proteins and by certain G protein beta/gamma subunits. PLC-L (for PLC-deleted in lung carcinoma) plays a role in inositol phospholipid-based intracellular signaling and contributes to the progression of human lung carcinoma.

1552
Ad-PLC(delta 4)

Ready-to-use Phospholipase C, delta 4 Adenovirus. Ad-PLC(delta 4), “Phospholipase C, delta 4”, PLCD4, PLC (Delta 4) adenovirus 1552

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Description (Vector)
PLCD4 encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer.
Gene ID
84812
Gene Name (Vector)
phospholipase C delta 4
Gene Symbol
PLCD4
HGNC ID
HGNC:9062
ORF Size (aa)
2289
ORF Size (bp)
2289 bp
RefSeq ID
NM_032726
RefSeq Synonyms
NM_032726, BC006355,
Species
human
UniGene ID
Hs.632528

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.