Hypoxia-inducible factor 1, alpha subunit inhibitor Adenovirus
Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1-alpha. Specifically, FIH-1 operates as an asparaginyl hydroxylase and catalyzes the hydroxylation of the beta-carbon of asparagine residue 803 within the C-terminal transactivation domain of HIF-1-alpha. This hyroxylation event blocks the association of HIF-1alpha with coactivators.
1551
Ad-HIF1AN/FIH1
Ready-to-use Hypoxia-inducible factor 1, alpha subunit inhibitor Adenovirus. Ad-HIF1AN/FIH1, “Hypoxia-inducible factor 1, alpha subunit inhibitor”, FIH1, HIF1AN, FIH-1 adenovirus 1551
Gene Reference Data
Alternate Names
factor inhibiting HIF1; factor inhibiting HIF-1; FIH1; FIH-1; hypoxia inducible factor 1 alpha subunit inhibitor; hypoxia-inducible factor 1-alpha inhibitor; hypoxia-inducible factor asparagine hydroxylase; peptide-aspartate beta-dioxygenase
Description (eCommerce)
Factor inhibiting HIF-1 (FIH-1) hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). FIH-1 functions as an oxygen sensor, and under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. FIH-1 is involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NWT6].
Gene ID
55662
Gene Name (eCommerce)
hypoxia inducible factor 1 subunit alpha inhibitor
Gene Name (Vector)
hypoxia inducible factor 1 alpha subunit inhibitor
Gene Symbol
HIF1AN
HGNC ID
HGNC:17113
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1050
ORF Size (bp)
1050 bp
Protein Name (eCommerce)
Hypoxia-inducible factor 1-alpha inhibitor
RefSeq ID
NM_017902
RefSeq Synonyms
NM_017902, BC007719,
Research Areas
Cardiovascular,Hypoxia,Notch Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
Factor inhibiting HIF-1 (FIH-1) hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). FIH-1 functions as an oxygen sensor, and under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. FIH-1 is involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NWT6].
UniGene ID
Hs.500788
UniProt ID (eCommerce)
Q9NWT6
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.