Pyruvate dehydrogenase kinase, isozyme 2 Adenovirus

Name 
Ad-PDK2
Cat No 
1548
Availability
Immediate
Categories
Adenovirus, Over-Expression

Glycolysis is an evolutionarily conserved series of ten chemical reactions that utilizes eleven enzymes to concomitantly generate pyruvate and ATP from glucose. Phospho-fructose kinase-2/fructose 2,6-bisphosphatase (PFK-2) stimulates the synthesis and degradation of fructose 2,6-bisphosphate. Pyruvate dehydrogenase (PDH) catalyzes the oxidative decarboxylation of pyruvate to generate acetyl-coenzyme A, thereby linking glycolysis to the TCA cycle with respect to substrate. The phosphorylation of PDH is catalyzed by pyruvate dehydrogenase kinase (PDK), the activity of which is stimulated by the products of PDH catalysis. TIM (Triosephosphate isomerase) exists as a homodimer and catalyzes the reaction of D-glyceraldehyde 3-phosphate into glycerone phosphate.

1548
Ad-PDK2

Ready-to-use Pyruvate dehydrogenase kinase, isozyme 2 Adenovirus. Ad-PDK2, “Pyruvate dehydrogenase kinase, isozyme 2”, PDK2 adenovirus 1548

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
PDHK2; PDKII
Description (Vector)
PDK2 encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
5164
Gene Name (Vector)
pyruvate dehydrogenase kinase 2
Gene Symbol
PDK2
HGNC ID
HGNC:8810
ORF Size (aa)
1224
ORF Size (bp)
1224 bp
RefSeq ID
NM_002611
RefSeq Synonyms
NM_002611, NM_001199900, NM_001199899, NM_001199898, BC063137, BC040478, BC005811,
Species
human
UniGene ID
Hs.256667

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.