Jun B proto-oncogene Adenovirus

Name 
Ad-JUN B
Cat No 
1535
Availability
Immediate
Categories
Adenovirus, Over-Expression

The activator protein-1 (AP-1) transcription factor consists of either Jun homodimers or Fos/Jun heterodimeric complexes, which bind the palindromic TRE sequence TGA(C/G)TCA. The Jun family includes c-Jun, Jun B and Jun D, while the Fos gene family members include c-Fos, Fos B, Fra-1 and Fra-2. In addition, certain ATF/CREB proteins form leucine zipper dimers with Fos and Jun, which exhibit different specificities for AP-1 and CRE DNA motifs. AP-1 transcription factor components are subject to regulation by both phosphorylation and by chemical oxidation of specific cysteine residues mapping within the DNA binding domains of Fos and Jun. Oxidation is reversible by a cellular redox/DNA repair protein designated Ref-1 (redox factor 1). JAB1 (Jun-activation domain-binding protein 1) potentiates transcription by either c-Jun or Jun D.

1535
Ad-JUN B

Ready-to-use Jun B proto-oncogene Adenovirus. Ad-JUN B, Jun B proto-oncogene, JUNB, JUN-B, JUN B adenovirus 1535

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
activator protein 1; AP-1; jun B proto-oncogene; transcription factor jun-B
Description (eCommerce)
JunB is a transcription factor that binds DNA as a homodimer or as a heterodimer with other members of the Jun/Fos family. JunB plays a role in regulating gene activity following the primary growth factor response. JunB binds to the DNA sequence 5'-TGA[CG]TCA-3' [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P17275].
Gene ID
3726
Gene Name (eCommerce)
JunB proto-oncogene, AP-1 transcription factor subunit
Gene Name (Vector)
JunB proto-oncogene, AP-1 transcription factor subunit
Gene Symbol
JUNB
HGNC ID
HGNC:6205
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1044
ORF Size (bp)
1044 bp
Protein Name (eCommerce)
Transcription factor jun-B
RefSeq ID
NM_002229
RefSeq Synonyms
NM_002229, BC009466, BC009465, BC004250,
Research Areas
B-cell Receptor Signaling,Cancer,Cardiovascular,Cell Cycle,Cell Division,Gene Expression,Immunology,Interleukin Signaling,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cardiovascular,cancer,cell_biology,cell_cycle,genetics,transcription_translation,immunology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
JunB is a transcription factor that binds DNA as a homodimer or as a heterodimer with other members of the Jun/Fos family. JunB plays a role in regulating gene activity following the primary growth factor response. JunB binds to the DNA sequence 5'-TGA[CG]TCA-3' [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P17275].
UniGene ID
Hs.25292
UniProt ID (eCommerce)
P17275

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.