Peroxisome proliferative activated receptor, delta Adenovirus

Name 
Ad-PPARb
Cat No 
1531
Availability
Immediate
Categories
Adenovirus, Over-Expression

The protein encoded by this gene is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR delta and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

1531
Ad-PPARb

Ready-to-use Peroxisome proliferative activated receptor, delta Adenovirus. Ad-PPAR-D, “Peroxisome proliferative activated receptor, delta”, FAAR, NUC1, NUCI, NR1C2, NUCII, PPARB, PPARD, PPAR-BETA, PPARb adenovirus 1531

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB
Description (Vector)
PPARD encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.
Gene ID
5467
Gene Name (Vector)
peroxisome proliferator activated receptor delta
Gene Symbol
PPARD
HGNC ID
HGNC:9235
ORF Size (aa)
1086
ORF Size (bp)
1086 bp
RefSeq ID
NM_006238
RefSeq Synonyms
NM_177435, NM_006238, NM_001171820, NM_001171819, NM_001171818, BC007578, BC002715,
Species
human
UniGene ID
Hs.696032

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.