Neutrophil cytosolic factor 2 Adenovirus
The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing gp91-phox, Nox4 and p22-phox, and the cytosolic proteins, p40-phox, p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome cytochrome b558 to form the active enzyme complex. Mox1 is largely similar to gp91 and is involved in regulating NADPH oxidase activity in non-phagocytic cells.
1518
Ad-p67Phox
Ready-to-use Neutrophil cytosolic factor 2 Adenovirus. Ad-p67Phox, Neutrophil cytosolic factor 2, NCF2, NOXA2, P67PHOX, P67-PHOX adenovirus 1518
Gene Reference Data
Alternate Names
NCF-2; NOXA2; P67-PHOX; P67PHOX
Description (Vector)
NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
4688
Gene Name (Vector)
neutrophil cytosolic factor 2
Gene Symbol
NCF2
HGNC ID
HGNC:7661
ORF Size (aa)
1581
ORF Size (bp)
1581 bp
RefSeq ID
NM_000433
RefSeq Synonyms
NM_001190794, NM_001190789, NM_001127651, NM_000433, BC001606,
Species
human
UniGene ID
Hs.587558
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.