Retinoid X receptor, beta Adenovirus

Name 
Ad-RXRb
Cat No 
1513
Availability
Immediate
Categories
Adenovirus, Over-Expression

Retinoids are metabolites of vitamin A (retinol) that represent an important group of signaling molecules during vertebrate development and tissue differentiation. Retinoic acid receptors (RARs) include RAR-alpha, RAR-beta and RAR-gamma, each of which has a high affinity for all transretinoic acids. Members of the retinoid X receptor (RXR) family, RXR-alpha, RXR-beta1, RXR-beta2 and RXR-gamma, are activated by 9-cis-retinoic acid, a stereo- and photoisomer of all transretinoic acids that is expressed in vivo in both liver and kidney and may represent a widely used hormone. The RAR-related orphan nuclear receptors (ROR) bind DNA as monomers and include ROR-alpha, ROR-beta and ROR-gamma. DAX-1 binds to retinoic acid response elements to mediate transcription. FXR (activated by farnesol and related metabolites) binds RXR to form a heterodimer, which subsequently binds IR-1 elements.

1513
Ad-RXRb

Ready-to-use Retinoid X receptor, beta Adenovirus. Ad-RXRb, “Retinoid X receptor, beta”, RXRB, NR2B2, DAUDI6, RCOR-1, H-2RIIBP adenovirus 1513

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
DAUDI6; H-2RIIBP; NR2B2; RCoR-1
Description (Vector)
RXRB encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. RXRB lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
6257
Gene Name (Vector)
retinoid X receptor beta
Gene Symbol
RXRB
HGNC ID
HGNC:10478
ORF Size (aa)
1602
ORF Size (bp)
1602 bp
RefSeq ID
NM_021976
RefSeq Synonyms
NM_021976, NM_001291989, NM_001270401, BC001167,
Species
human
UniGene ID
Hs.388034

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.