v-raf murine sarcoma 3611 viral oncogene homolog Gene Adenovirus

Name 
Ad-A-Raf
Cat No 
1510
Availability
Immediate
Categories
Adenovirus, Over-Expression

The Raf kinases are important intermediates in signal transduction pathways. Raf-1, the prototype member of this gene family, is a 72-76 kDa cytoplasmic protein with intrinsic serine/threonine kinase activity, is broadly expressed in many cell types and is the cellular homolog of the viral oncogene, v-Raf. Other members of the Raf gene family include Raf-A and Raf-B. Raf-1 phosphorylates and thereby activates MEK (also designated MAP kinase kinase). Ras proteins bind Raf-1, but only when Ras is in its active GTP-binding state. This interaction results in Raf-mediated MEK activation. Two more recently described Raf-related proteins, Ksr-1 and Tak1 (TGF-beta-activated kinase), function as upstream regulators of Ras signaling pathways.

1510
Ad-A-Raf

Ready-to-use v-raf murine sarcoma 3611 viral oncogene homolog Gene Adenovirus. Ad-A-Raf, v-raf murine sarcoma 3611 viral oncogene homolog Gene , ARAF, PKS2, A-RAF, ARAF1, RAFA1 adenovirus 1510

$690.00
Request Volume Pricing or Customization

Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
A-RAF; A-Raf proto-oncogene serine/threonine-protein kinase; ARAF1; Oncogene ARAF1; PKS2; Proto-oncogene A-Raf; proto-oncogene A-Raf-1; proto-oncogene Pks; RAFA1; Ras-binding protein DA-Raf; serine/threonine-protein kinase A-Raf; v-raf murine sarcoma 3611 viral oncogene homolog 1; v-raf murine sarcoma 3611 viral oncogene-like protein
Description (eCommerce)
A-RAF is a member of the RAF family of serine/threonine kinases. In mammals, there are three members: A-,B-, and C-RAF. A-RAF plays a role in the transduction of cellular signals that promote cell growth and development.
Description (Vector)
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
369
Gene Name (eCommerce)
A-Raf proto-oncogene, serine/threonine kinase
Gene Name (Vector)
A-Raf proto-oncogene, serine/threonine kinase
Gene Symbol
ARAF
HGNC ID
HGNC:646
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1821
ORF Size (bp)
1821 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase A-Raf
RefSeq ID
NM_001654
RefSeq Synonyms
NM_001654, NM_001256197, NM_001256196, BC007514, BC002466,
Research Areas
Apoptosis,B-cell Receptor Signaling,Bladder Cancer,Breast Cancer,Cancer,Cardiovascular,Colorectal Cancer,Cytoskeleton,EGFR Signaling,EPO Signaling,FGF Signaling,Glioma,GPCR Signaling,Host-Virus Interactions,Immunology,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kidney Cancer,Kinase/Phosphatase,Leukemia,Lung Cancer,MAPK Signaling,Mitochondrion,Neurobiology,NGF Signaling,Prostate Cancer,Signal Transduction,T-cell Receptor Signaling,VEGF Signaling,Zinc-finger
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
A-RAF is a member of the RAF family of serine/threonine kinases. In mammals, there are three members: A-,B-, and C-RAF. A-RAF plays a role in the transduction of cellular signals that promote cell growth and development.
UniGene ID
Hs.446641
UniProt ID (eCommerce)
P10398

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.