human EIF6 Adenovirus

Name 
Ad-h-EIF6
Cat No 
ADV-207810
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human EIF6.

ADV-207810
Ad-h-EIF6

Ready-to-use Adenovirus expressing Human EIF6 (eukaryotic translation initiation factor 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
b(2)gcn; B(2)GCN homolog; B4 integrin interactor; CAB; EIF3A; eIF-6; eukaryotic translation initiation factor 3A; eukaryotic translation initiation factor 6; ITGB4BP; p27 beta-4 integrin-binding protein; p27(BBP); p27BBP
Description (eCommerce)
Eukaryotic translation initiation factor 6 (eIF6) is insoluble and found both in the nucleus and in the cytoplasm. eIF6 can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits.eIF6 binds to the fibronectin type III domains of ITGB4 in hemidesmosomes and may help link ITGB4 to the intermediate filament cytoskeleton [taken from NCBI Entrez Gene (Gene ID: 3692].
Description (Vector)
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene.
Gene ID
3692
Gene Name (eCommerce)
eukaryotic translation initiation factor 6
Gene Name (Vector)
eukaryotic translation initiation factor 6
Gene Symbol
EIF6
HGNC ID
HGNC:6159
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
738
ORF Size (bp)
738 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 6
RefSeq ID
NM_002212
RefSeq Synonyms
NM_181468, NM_181466, NM_002212, NM_001267810, BC019305, BC011845, BC001119,
Research Areas
Signal Transduction,Translational Control
Research Areas (Faceted)
cell_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
Eukaryotic translation initiation factor 6 (eIF6) is insoluble and found both in the nucleus and in the cytoplasm. eIF6 can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits.eIF6 binds to the fibronectin type III domains of ITGB4 in hemidesmosomes and may help link ITGB4 to the intermediate filament cytoskeleton [taken from NCBI Entrez Gene (Gene ID: 3692].
UniGene ID
Hs.654848
UniProt ID (eCommerce)
P56537

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.