Sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) Adenovirus
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The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. The human sirtuins, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT1 is widely expressed and regulates p53 function through its deacetylation at lysine 382.
1499
Ad-SIRT3
Ready-to-use Sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) Adenovirus. Ad-SIRT3, Sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae), SIRT3,SIR2L3 adenovirus 1499
Original price was: $475.00.$332.50Current price is: $332.50.
Gene Reference Data
Alternate Names
SIR2L3
Description (Vector)
SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.
Gene ID
23410
Gene Name (Vector)
sirtuin 3
Gene Symbol
SIRT3
HGNC ID
HGNC:14931
ORF Size (aa)
1200
ORF Size (bp)
1200 bp
RefSeq ID
NM_012239
RefSeq Synonyms
NM_012239, NM_001017524, BC001042,
Species
human
UniGene ID
Hs.716456
Related Citations
- The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other’s activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy. A Kanwal,etc, (2019), The FASEB Journal
- Inhibition of glycolytic metabolism in glioblastoma cells by Pt3glc combinated with PI3K inhibitor via SIRT3-mediated mitochondrial and PI3K/Akt-MAPK pathway. G Wang, etc, (2018), Journal of Cellular Physiology
- SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage. Bindu S, etc, (2016), American Journal of Physiology - Lung Cellular and Molecular Physiology
- LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2a/Notch3 pathways. H Zeng, etc, (2016), Scientific Reports
- SIRT3 regulates a-SMA production through the succinate dehydrogenase-GPR91 pathway in hepatic stellate cells. Eun-Hee Cho, (2016), JBC
- SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating GSK3ß. NR Sundaresan,, (2015), Molecular and Cellular Biology
- SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress. SA Samant, etc, (2013), MCB
- Sirt3 Is A Stress-Responsive Deacetylase In Cardiomyocytes That Protects Cells From Stress-Mediated Cell Death By Deacetylation Of Ku70. Sundaresan, N., etc., (2008), Molecular and Cellular Biology
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.