Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Adenovirus

Name 
Ad-IKK-gamma
Cat No 
1455
Availability
Immediate
Categories
Adenovirus, Over-Expression

The IkB kinases, IKK(alpha) (previously designated CHUK) and IKK(beta), are members of the helix-loop-helix, leucine zipper family of interacting proteins. IKK(alpha) specifically phosphorylates IkB(alpha) on the sites, serines 32 and 36, to trigger its degradation. The IKK complex appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKK(alpha) is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation. The functional IKK complex contains three subunits, IKK(alpha), IKK(beta) and IKK(gamma) (also designated NEMO, for NFkB essential modulator), and each appear to make essential contributions to IkB phosphorylation. TANK binding kinase (TBK1), also designated T2K, is an IKK-related kinase that complexes with TRAF2 and TANK in the NF?B activation pathway. IKK-i is an IKK-related serine/threonine kinase that is expressed in immune cells and is inducible by LPS, TNF(alpha), IL-1 and IL-6. Overexpression of IKK-i results in IkB(alpha) phosphorylation and NFkB activation.

1455
Ad-IKK-gamma

Ready-to-use Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Adenovirus. Ad-IKK-gamma, “Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma”, IP,IP2,FIP3,NEMO,FIP-3,FIP3P,IKBKG,IKK-GAMMA adenovirus 1455

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
AMCBX1; FIP-3; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Description (Vector)
IKBKG encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
Gene ID
8517
Gene Name (Vector)
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Gene Symbol
IKBKG
HGNC ID
HGNC:5961
ORF Size (aa)
1260
ORF Size (bp)
1260 bp
RefSeq ID
NM_003639
RefSeq Synonyms
NM_003639, NM_001321397, NM_001321396, NM_001145255, NM_001099857, NM_001099856, BC050612, BC046922, BC012114, BC000299,
Species
human
UniGene ID
Hs.43505

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.