Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha Adenovirus

Name 
Ad-CaMKII(alpha)
Cat No 
1438
Availability
Immediate
Categories
Adenovirus, Over-Expression

Ca2+/calmodulin-dependent protein kinases (CaM kinases) compose a structurally related subfamily of serine/threonine kinases. Members of this family include phosphorylase kinase, myosin light chain kinases (MLCKs) and CaM kinases (CaMKs) I, II, III and IV. Of these, CaMKII comprises of four distinct subunits, alpha, beta, gamma and delta. Upstream regulators of CaMKI and CaMKIV, designated CaMKK and CaMKK(beta), function to activate CaMKI by specific phosphorylation at threonine 177. MLCK isoforms include non-muscle MLCK, smooth muscle MLCK and skeletal muscle MLCK (MLCKSK).

1438
Ad-CaMKII(alpha)

Ready-to-use Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha Adenovirus. Ad-CaMKII(alpha), Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, CAMKA,CAMK2A,KIAA0968 adenovirus 1438

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
CAMKA
Description (Vector)
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
Gene ID
815
Gene Name (Vector)
calcium/calmodulin dependent protein kinase II alpha
Gene Symbol
CAMK2A
HGNC ID
HGNC:1460
ORF Size (aa)
1437
ORF Size (bp)
1437 bp
RefSeq ID
NM_171825
RefSeq Synonyms
NM_171825, NM_015981, BC040457,
Species
human
UniGene ID
Hs.716391

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.