Paired box gene 6 Adenovirus
This gene encodes paired box gene 6, one of many human homologues of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause aniridia as well as Peter’s anomaly, both ocular diseases
1379
Ad-Pax6
Ready-to-use Paired box gene 6 Adenovirus. Ad-Pax6, Paired box gene 6, AN,AN2,MGDA,PAX6,WAGR,D11S812E adenovirus 1379
Gene Reference Data
Alternate Names
AN; AN2; aniridia type II protein; ASGD5; D11S812E; FVH1; MGDA; oculorhombin; paired box homeotic gene-6; paired box protein Pax-6; WAGR
Description (eCommerce)
PAX6/AN is a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the ey [taken from NCBI Entrez Gene (Gene ID: 5080)].
Description (Vector)
PAX6 encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA and function as regulators of gene transcription. PAX6 is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
5080
Gene Name (eCommerce)
paired box 6
Gene Name (Vector)
paired box 6
Gene Symbol
PAX6
HGNC ID
HGNC:8620
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1269
ORF Size (bp)
1269 bp
Protein Name (eCommerce)
Paired box protein Pax-6
RefSeq ID
NM_000280
RefSeq Synonyms
NM_001604, NM_001310161, NM_001310160, NM_001310159, NM_001310158, NM_001258465, NM_001258464, NM_001258463, NM_001258462, NM_001127612, NM_000280, BC011953,
Research Areas
Axon Guidance,Cardiac Development,Cardiology,Cardiovascular,Gene Expression,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Neurogenesis,RNA Binding,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PAX6/AN is a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the ey [taken from NCBI Entrez Gene (Gene ID: 5080)].
UniGene ID
Hs.716008
UniProt ID (eCommerce)
P26367
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.