Spleen tyrosine kinase Adenovirus

Name 
Ad-Syk
Cat No 
1362
Availability
Immediate
Categories
Adenovirus, Over-Expression

Syk p72 and ZAP-70 resemble the Src family protein tyrosine kinases in that they have a C-terminal catalytic domain, but differ in that they are characterized by two SH2 domains but no SH3 domains. Syk p72 kinase fused to the transmembrane and extracellular domains of CD7 and CD16, respectively, can induce complete T cell activation, implying the involvement of the Syk/ZAP family proteins in T cell activation. In contrast, the ZAP-70 kinase is insufficient for complete T cell activation unless it is coaggregated with a Fyn p59-containing chimera, suggesting that regulation of ZAP-70 activity may require a functional interaction with Src family kinases.

1362
Ad-Syk

Ready-to-use Spleen tyrosine kinase Adenovirus. Ad-Syk, Spleen tyrosine kinase, Syk adenovirus 1362

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
p72-Syk; spleen tyrosine kinase; tyrosine-protein kinase SYK
Description (eCommerce)
SYK (spleen tyrosine kinase) is a ubiquitously expressed tyrosine kinase that functions in mediating B and T-cell receptor signaling and is also important to various aspects of leukocyte function that involve cytoskeleton remodeling. In mediating hematopoietic cell signaling, SYK is a substrate of src family kinase activity and is a key-regulator of Akt kinase activity. SYK has also been found to be highly expressed in the mammary gland and has been shown to inhibit tumor growth and metastasis. Invasive breast tumor cell lines have been shown to exhibit reduced or absent levels of SYK, further implicating a role in tumorigenesis and metastasis.
Description (Vector)
SYK encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
6850
Gene Name (eCommerce)
spleen associated tyrosine kinase
Gene Name (Vector)
spleen associated tyrosine kinase
Gene Symbol
SYK
HGNC ID
HGNC:11491
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1839
ORF Size (bp)
1839 bp
Protein Name (eCommerce)
Tyrosine-protein kinase SYK
RefSeq ID
NM_003177
RefSeq Synonyms
NM_003177, NM_001174168, NM_001174167, NM_001135052, BC011399, BC002962, BC001645,
Research Areas
Angiogenesis,B-cell Receptor Signaling,Cancer,Cardiovascular,CD95/FAS Signaling,Cytokine Signaling,EPO Signaling,Fc Receptor Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Neurobiology,NF-kB Signaling,PI3K/Akt Signaling,RANKL-RANK Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Toll-like Receptor Signaling,VEGF Signaling,Viral Carcinogenesis
Research Areas (Faceted)
cardiovascular,cancer,developmental_biology,signal_transduction,immunology,infectious_disease,immunology,signal_transduction,cell_biology,neurobiology,signal_transduction,immunology,signal_transduction,cancer,infectious_disease
Species
human
Target Sentence
SYK (spleen tyrosine kinase) is a ubiquitously expressed tyrosine kinase that functions in mediating B and T-cell receptor signaling and is also important to various aspects of leukocyte function that involve cytoskeleton remodeling. In mediating hematopoietic cell signaling, SYK is a substrate of src family kinase activity and is a key-regulator of Akt kinase activity. SYK has also been found to be highly expressed in the mammary gland and has been shown to inhibit tumor growth and metastasis. Invasive breast tumor cell lines have been shown to exhibit reduced or absent levels of SYK, further implicating a role in tumorigenesis and metastasis.
UniGene ID
Hs.371720
UniProt ID (eCommerce)
P43405

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.