human COMT Adenovirus
This is an Adenovirus expressing Human COMT.
ADV-205753
Ad-h-COMT
Ready-to-use Adenovirus expressing Human COMT (catechol-O-methyltransferase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
catechol O-methyltransferase; catechol-O-methyltransferase isoform; epididymis secretory sperm binding protein Li 98n; HEL-S-98n; testicular tissue protein Li 42
Description (eCommerce)
Catechol O-mehtyltransferase (COMT) catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P21964].
Description (Vector)
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Gene ID
1312
Gene Name (eCommerce)
catechol-O-methyltransferase
Gene Name (Vector)
catechol-O-methyltransferase
Gene Symbol
COMT
HGNC ID
HGNC:2228
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
549
ORF Size (bp)
549 bp
Protein Name (eCommerce)
Catechol O-methyltransferase
RefSeq ID
NM_000754
RefSeq Synonyms
NM_007310, NM_001135162, NM_001135161, NM_000754, BC100018, BC011935, BC005867, BC000419,
Research Areas
Metabolism/Metabolic Process,Methyltransferase,Mitochondrion,Neurobiology,Neurodegeneration,Parkinson's Disease
Research Areas (Faceted)
cell_biology,metabolism,neurobiology
Species
human
Target Sentence
Catechol O-mehtyltransferase (COMT) catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P21964].
UniGene ID
Hs.713616
UniProt ID (eCommerce)
P21964
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.