human CBL Adenovirus

Cas-Br-M (murine) ecotropic retroviral transforming sequence; casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; C-CBL; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; signal transduction protein CBL

The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation [taken from NCBI GeneID:867].

CBL is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. CBL has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

867

Cbl proto-oncogene

Cbl proto-oncogene

CBL

HGNC:1541

9606.0

2721

2721 bp

E3 ubiquitin-protein ligase CBL

NM_005188

NM_005188, BC136463, BC132733,

Angiogenesis,Apoptosis,B-cell Receptor Signaling,Breast Cancer,Cancer,Cytokine Signaling,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,Glioma,GPCR Signaling,HGF Signaling,IFN Signaling,Immunology,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Leukemia,Lung Cancer,Neurobiology,PDGF Signaling,Prolactin Signaling,RANKL-RANK Signaling,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,Ubiquitination,VEGF Signaling,Zinc-finger

cancer,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction,stem_cell_biology,transcription_translation

human

The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation [taken from NCBI GeneID:867].

Hs.504096

P22681