human BCAR3 Adenovirus

Name 
Ad-h-BCAR3
Cat No 
ADV-202012
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human AP1S2.

ADV-202012
Ad-h-BCAR3

Ready-to-use Adenovirus expressing Human BCAR3 (breast cancer anti-estrogen resistance 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AND-34; breast cancer anti-estrogen resistance 3; breast cancer antiestrogen resistance 3 protein; breast cancer anti-estrogen resistance protein 3; dJ1033H22.2 (breast cancer anti-estrogen resistance 3); epididymis secretory sperm binding protein; novel SH2-containing protein 2; NSP2; SH2 domain-containing protein 3B; SH2D3B
Description (eCommerce)
BCAR3 (breast cancer anti-estrogen resistance 3) was originally identified as a factor that confers resistance to anti-estrogens in breast cancer cells. BCAR3 contains a Ras-GEF domain and an SH2 domain. It is related to SHEP1 and NSP1 and is thought to also play a role as an adaptor protein that mediates integrin signaling to modulate cell adhesion and migration.
Description (Vector)
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
8412
Gene Name (eCommerce)
BCAR3, NSP family adaptor protein
Gene Name (Vector)
breast cancer anti-estrogen resistance 3
Gene Symbol
BCAR3
HGNC ID
HGNC:973
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2478
ORF Size (bp)
2478 bp
Protein Name (eCommerce)
Breast cancer anti-estrogen resistance protein 3
RefSeq ID
NM_003567
RefSeq Synonyms
NM_003567, NM_001308251, NM_001261410, NM_001261409, NM_001261408, BC039895,
Research Areas
EGFR Signaling,Signal Transduction
Research Areas (Faceted)
signal_transduction
Species
human
Target Sentence
BCAR3 (breast cancer anti-estrogen resistance 3) was originally identified as a factor that confers resistance to anti-estrogens in breast cancer cells. BCAR3 contains a Ras-GEF domain and an SH2 domain. It is related to SHEP1 and NSP1 and is thought to also play a role as an adaptor protein that mediates integrin signaling to modulate cell adhesion and migration.
UniGene ID
Hs.36958
UniProt ID (eCommerce)
O75815

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.