human AXIN2 Adenovirus
This is an Adenovirus expressing Human ANKS1A.
ADV-201857
Ad-h-AXIN2
Ready-to-use Adenovirus expressing Human AXIN2 (axin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AXIL; ODCRCS
Description (Vector)
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Gene ID
8313
Gene Name (Vector)
axin 2
Gene Symbol
AXIN2
HGNC ID
HGNC:904
ORF Size (aa)
2532
ORF Size (bp)
2532 bp
RefSeq ID
NM_004655
RefSeq Synonyms
NM_004655, BC143244, BC101533, BC006295,
Species
human
UniGene ID
Hs.156527
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.