human APOC3 Adenovirus
This is an Adenovirus expressing Human APOC3.
ADV-201194
Ad-h-APOC3
Ready-to-use Adenovirus expressing Human APOC3 (apolipoprotein C3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
APOCIII; Apo-CIII; ApoC-III; Apolipoprotein C3; apolipoprotein C-III
Description (eCommerce)
Apo CIII contains 79 amino acid residues. The m.w. is 8.7 kDa (Brewer et al., 1974). It may inhibit the activation of lipoprotein lipase by apo CIII. Apo CIII is a constituent of both apoB- and apoAI-containing lipoproteins in the circulation. Apo CIII plays a pivotal role in regulating the plasma metabolism of VLDL, IDL, and LDL, primarily by inhibiting receptor-mediated uptake of these lipoproteins by the liver. (Sehayek and Eisenberg 1991, Aalto-Setala et al., 1992, Zheng et al., 2007)
Description (Vector)
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
Gene ID
345
Gene Name (eCommerce)
apolipoprotein C3
Gene Name (Vector)
apolipoprotein C3
Gene Symbol
APOC3
HGNC ID
HGNC:610
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
300
ORF Size (bp)
300 bp
Protein Name (eCommerce)
Apolipoprotein C-III
RefSeq ID
NM_000040
RefSeq Synonyms
NM_000040, BC134419, BC121081, BC027977,
Research Areas
Cardiovascular
Research Areas (Faceted)
cardiovascular
Species
human
Target Sentence
Apo CIII contains 79 amino acid residues. The m.w. is 8.7 kDa (Brewer et al., 1974). It may inhibit the activation of lipoprotein lipase by apo CIII. Apo CIII is a constituent of both apoB- and apoAI-containing lipoproteins in the circulation. Apo CIII plays a pivotal role in regulating the plasma metabolism of VLDL, IDL, and LDL, primarily by inhibiting receptor-mediated uptake of these lipoproteins by the liver. (Sehayek and Eisenberg 1991, Aalto-Setala et al., 1992, Zheng et al., 2007)
UniGene ID
Hs.73849
UniProt ID (eCommerce)
P02656
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.