human APEX2 Adenovirus
This is an Adenovirus expressing Human AHCY.
ADV-201142
Ad-h-APEX2
Ready-to-use Adenovirus expressing Human APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
APE2; APEXL2; XTH2; ZGRF2
Description (Vector)
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).
Gene ID
27301
Gene Name (Vector)
apurinic/apyrimidinic endodeoxyribonuclease 2
Gene Symbol
APEX2
HGNC ID
HGNC:17889
ORF Size (aa)
1557
ORF Size (bp)
1557 bp
RefSeq ID
NM_014481
RefSeq Synonyms
NM_014481, NM_001271748, BC002959,
Species
human
UniGene ID
Hs.659558
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.