human APEH Adenovirus

Name 
Ad-h-APEH
Cat No 
ADV-201134
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human AHCTF1.

ADV-201134
Ad-h-APEH

Ready-to-use Adenovirus expressing Human APEH (acylaminoacyl-peptide hydrolase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AARE; ACPH; acylamino-acid-releasing enzyme; acylaminoacyl-peptidase; acyl-peptide hydrolase; APH; D3F15S2; D3S48E; DNF15S2; N-acylaminoacyl-peptide hydrolase; OPH; oxidized protein hydrolase
Description (eCommerce)
APEH catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P13798].
Description (Vector)
APEH encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. APEH is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma.
Gene ID
327
Gene Name (eCommerce)
acylaminoacyl-peptide hydrolase
Gene Name (Vector)
acylaminoacyl-peptide hydrolase
Gene Symbol
APEH
HGNC ID
HGNC:586
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2199
ORF Size (bp)
2199 bp
Protein Name (eCommerce)
Acylamino-acid-releasing enzyme
RefSeq ID
NM_001640
RefSeq Synonyms
NM_001640, BC001826, BC001499, BC000362,
Research Areas
Cell Biology
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
APEH catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P13798].
UniGene ID
Hs.517969
UniProt ID (eCommerce)
P13798

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.