human AKT1S1 Adenovirus

Name 
Ad-h-AKT1S1
Cat No 
ADV-200704
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human AKT1S1.

ADV-200704
Ad-h-AKT1S1

Ready-to-use Adenovirus expressing Human AKT1S1 (AKT1 substrate 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
40 kDa proline-rich AKT substrate; AKT1 substrate 1 (proline rich); Lobe; PRAS40; proline-rich AKT1 substrate 1
Description (eCommerce)
AktS1/PRAS40 interacts with raptor as a component of the mammalian target of rapamycin complex 1 (mTORC1). One study suggests that AktS1/PRAS40 may function to regulate mTORC1 kinase activity by inhibiting substrate binding. Another study suggests that AktS1/PRAS40 functions downstream of mTORC1 and upstream from its effectors S6K1, and 4E-BP1.
Description (Vector)
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 (PubMed 12524439)).(supplied by OMIM, Mar 2008)
Gene ID
84335
Gene Name (eCommerce)
AKT1 substrate 1
Gene Name (Vector)
AKT1 substrate 1
Gene Symbol
AKT1S1
HGNC ID
HGNC:28426
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
771
ORF Size (bp)
771 bp
Protein Name (eCommerce)
Proline-rich AKT1 substrate 1
RefSeq ID
NM_032375
RefSeq Synonyms
NM_032375, NM_001278160, NM_001278159, NM_001098633, NM_001098632, BC051844, BC016043, BC015562, BC007416,
Research Areas
Apoptosis,Autophagy,B-cell Receptor Signaling,Cancer,EGFR Signaling,EGFR Signaling in Cancer,Fc Receptor Signaling,FGF Signaling,HGF Signaling,Immunology,Innate Immunity,LKB1 Signaling,Metabolism/Metabolic Process,mTOR Signaling,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,SCF-KIT Signaling,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,immunology,metabolism,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
AktS1/PRAS40 interacts with raptor as a component of the mammalian target of rapamycin complex 1 (mTORC1). One study suggests that AktS1/PRAS40 may function to regulate mTORC1 kinase activity by inhibiting substrate binding. Another study suggests that AktS1/PRAS40 functions downstream of mTORC1 and upstream from its effectors S6K1, and 4E-BP1.
UniGene ID
Hs.515542
UniProt ID (eCommerce)
Q96B36

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.