mouse CDKN1A Over-expression AAV

Name 
AAV-m-CDKN1A
Cat No 
AAV-277593
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Cdkn1a.

AAV-277593
AAV-m-CDKN1A

Ready-to-use AAV expressing Mouse Cdkn1a (cyclin-dependent kinase inhibitor 1A (P21)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAP20; CDKI; Cdkn1; CIP1; mda6; P21; p21Cip1; p21WAF; SDI1; Waf1
Description (Vector)
CDKN1A may be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Gene ID
12575
Gene Name (Vector)
cyclin-dependent kinase inhibitor 1A (P21)
Gene Symbol
Cdkn1a
ORF Size (aa)
480
ORF Size (bp)
480 bp
RefSeq ID
NM_007669
RefSeq Synonyms
NM_007669, NM_001111099, BC002043,
Species
mouse
UniGene ID
Mm.477981

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.